Sea-blue-colored histiocytes associated with bone marrow granulomas.

Sea blue histiocytosis: a common abnormality of the bone marrow in myelodysplastic syndromes.

AIMS To determine whether myelodysplastic syndromes (MDS) are associated with sea blue histiocytosis in the bone marrow. METHODS A retrospective review of bone marrow aspirates from 35 patients presenting consecutively with MDS and from 20 patients with each of the following: normal marrow appearance (routine staging for non-Hodgkin's lymphoma), polycythaemia rubra vera, immune thrombocytopen...

Sea-blue histiocytes and Gaucher cells in bone marrow of patients with chronic myeloid leukaemia.

A retrospective study of 211 bone marrow aspirates from patients with chronic myeloid leukaemia (CML) was undertaken to assess the incidence of Gaucher cells and sea-blue histiocytes. A significant correlation between the presence of these cells and prolonged survival was seen. Such storage histiocytes occurred most often during periods of relapsed chronic phase. This study shows that Gaucher c...

Sea-blue histiocytes in bone marrow aspiration sample: what is the importance?

The sea-blue histiocyte syndrome with hepatic porphyria and infectious mononucleosis.

The syndrome of sea-blue histiocyte, hepatic porphyria, and infectious mononucleosis occurring simultaneously in a young girl is described. The cytochemical staining character of the bone marrow histiocytes strongly suggested that the storage material was glycolipid. The possible relationship between the multiple disorders in the same patient is discussed.

Is it a sea-blue histiocyte?

In the “Images in Hematology’’ section of the Journal, And›ç et al. [1] briefly presented sea-blue histiocytes in a 45-year-old woman with type B Niemann-Pick disease [2,3]. I believe the cell photographed by the authors is fairly typical for Niemann-Pick disease with few nuclear remnants and superimposed lymphocytes. In my opinion, it is not typical for sea-blue histiocytes. We have seen sea-b...